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Over time, the brain adjusts to these elevated dopamine levels, leading to tolerance (requiring more nicotine to achieve the same effect) and dependence (needing nicotine to function normally)

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Extremely rare sample card from the Yum Yum Tobacco series of 1888 features an extraordinarily bold "in action" woodcut of legendary Hall of Famer John Clarkson with the Boston Nationals

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It also causes precancerous lesions in the oral cavity Tobacco contains nicotine which is habit forming and very addictive